Detailed view for Smp_120700.1

Basic information

TDR Targets ID: 284525
Schistosoma mansoni, cofilin actophorin
Source Database / ID:  GeneDB

pI: 6.8409 | Length (AA): 135 | MW (Da): 15726 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00241   Cofilin/tropomyosin-type actin-binding protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0030042   actin filament depolymerization  
GO:0015629   actin cytoskeleton  
GO:0005622   intracellular  
GO:0003779   actin binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 135 1tvj (A) 1 153 29.00 0 1 1.2488 -0.16
3 123 2i2q (A) 4 123 28.00 0 0.61 1.2401 -0.16
4 135 5ivu (A) 6 138 40.00 0 1 1.52968 -1.04
4 135 1cnu (A) 2 133 33.00 0 1 1.46958 -1.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127118)

Species Accession Gene Product
Arabidopsis thaliana AT3G46010   actin depolymerizing factor 1
Arabidopsis thaliana AT4G25590   actin depolymerizing factor 7
Arabidopsis thaliana AT3G46000   actin depolymerizing factor 2
Arabidopsis thaliana AT1G01750   actin depolymerizing factor 11
Arabidopsis thaliana AT5G59880   actin depolymerizing factor 3
Arabidopsis thaliana AT5G59890   actin depolymerizing factor 4
Arabidopsis thaliana AT4G00680   actin depolymerizing factor 8
Arabidopsis thaliana AT5G52360   actin depolymerizing factor 10
Brugia malayi Bm1_22990   actin-depolymerizing factor 1
Caenorhabditis elegans CELE_C38C3.5   Protein UNC-60, isoform A
Cryptosporidium hominis Chro.50095   actin depolymerizing factor-related
Cryptosporidium parvum cgd5_2800   actin depolymerizing factor
Dictyostelium discoideum DDB_G0277833   hypothetical protein
Dictyostelium discoideum DDB_G0283367   hypothetical protein
Dictyostelium discoideum DDB_G0291970   hypothetical protein
Drosophila melanogaster Dmel_CG4254   twinstar
Drosophila melanogaster Dmel_CG6873   CG6873 gene product from transcript CG6873-RA
Echinococcus granulosus EgrG_000528800   Actin binding cofilin tropomyosin type
Echinococcus granulosus EgrG_000528900   actin depolymerizing factor
Entamoeba histolytica EHI_197480   actophorin, putative
Echinococcus multilocularis EmuJ_000528900   actin depolymerizing factor
Echinococcus multilocularis EmuJ_000528800   Actin binding, cofilin tropomyosin type
Homo sapiens ENSG00000172757   cofilin 1 (non-muscle)
Homo sapiens ENSG00000165410   cofilin 2 (muscle)
Leishmania braziliensis LbrM.29.0450   cofilin-like protein
Leishmania donovani LdBPK_290520.1   cofilin-like protein
Leishmania infantum LinJ.29.0520   ADF/Cofilin
Leishmania major LmjF.29.0510   ADF/Cofilin
Leishmania mexicana LmxM.08_29.0510   cofilin-like protein
Loa Loa (eye worm) LOAG_06843   uncoordinated protein 60
Loa Loa (eye worm) LOAG_00661   actin-depolymerizing factor 1
Loa Loa (eye worm) LOAG_06844   actin-depolymerizing factor 1
Mus musculus ENSMUSG00000062929   cofilin 2, muscle
Mus musculus 12631   cofilin 1, non-muscle
Neospora caninum NCLIV_012510   hypothetical protein
Oryza sativa 4334594   Os03g0820500
Oryza sativa 4343240   Os07g0484200
Oryza sativa 4330233   Os02g0663800
Oryza sativa 4334595   Os03g0820600
Oryza sativa 4337605   Os05g0113400
Oryza sativa 4336622   Os04g0555700
Plasmodium berghei PBANKA_1137500   actin-depolymerizing factor 2
Plasmodium falciparum PF3D7_1361400   actin-depolymerizing factor 2
Plasmodium knowlesi PKNH_1109900   actin-depolymerizing factor 2, putative
Plasmodium vivax PVX_115030   actin-depolymerizing factor 2, putative
Plasmodium yoelii PY01091   actin-depolymerizing factor 3
Saccharomyces cerevisiae YLL050C   cofilin
Schistosoma japonicum Sjp_0207400   ko:K05765 cofilin, putative
Schistosoma mansoni Smp_120700.1   cofilin actophorin
Schistosoma mansoni Smp_086590   actin-depolymerizing factor
Schmidtea mediterranea mk4.027380.00  
Schmidtea mediterranea mk4.000142.08  
Schmidtea mediterranea mk4.013858.00  
Trypanosoma brucei gambiense Tbg972.3.5840   cofilin/actin depolymerizing factor, putative
Trypanosoma brucei Tb927.3.5180   ADF/Cofilin
Trypanosoma congolense TcIL3000_3_3160   cofilin/actin depolymerizing factor, putative
Trypanosoma cruzi TcCLB.508411.10   cofilin/actin depolymerizing factor, putative
Trypanosoma cruzi TcCLB.510145.20   cofilin/actin depolymerizing factor, putative
Toxoplasma gondii TGME49_220400   actin depolymerizing factor ADF
Trichomonas vaginalis TVAG_192620   actin depolymerizing factor, putative

Essentiality

Smp_120700.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.5180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.5180 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.5180 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.5180 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C38C3.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C38C3.5 Caenorhabditis elegans larval lethal wormbase
CELE_C38C3.5 Caenorhabditis elegans slow growth wormbase
CELE_C38C3.5 Caenorhabditis elegans sterile wormbase
YLL050C Saccharomyces cerevisiae inviable yeastgenome
TGME49_220400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_120700.1 (Schistosoma mansoni), cofilin actophorin
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